RESIDUAL PLATELET REACTIVITY DURING THERAPY WITH INHIBITORS OF CYCLOOXIGENASE OR ADENOSINE DIPHOSPHATE RECEPTORS
نویسندگان
چکیده
منابع مشابه
A Bigger Look Into the "Therapeutic Window" of Platelet Reactivity to Adenosine Diphosphate.
A decade ago, small observational studies using light transmittance aggregometry suggested that post-stenting ischemic event occurrences were not linearly related to ontreatment platelet reactivity (OPR) levels but instead largely occurred above a moderate threshold level (1,2). For example, in the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study of 20 patients with ...
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Several prospective studies have shown that high on-clopidogrel platelet reactivity (HPR) in patients undergoing percutaneous coronary intervention (PCI) is a risk factor for ischemic events. All studies were insufficiently powered to detect differences in stroke between patients with HPR and those without. Therefore, we performed a systematic review and meta-analysis of available publications ...
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Dual antiplatelet therapy with aspirin and a P2Y12 receptor blocker is a key strategy to reduce platelet reactivity and to prevent thrombotic events in patients treated with percutaneous coronary intervention. In an earlier consensus document, we proposed cutoff values for high on-treatment platelet reactivity to adenosine diphosphate (ADP) associated with post-percutaneous coronary interventio...
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One hundred and seven patients with congestive heart failure, myocardial infarction and arteriosclerotic heart disease were studied by adenosine diphosphate-induced platelet aggregation, fibrinogen levels and ethanol gelation test. Both increases and decreases in platelet aggregation were observed. A significantly high percentage of patients showed a decreased platelet aggregation which was esp...
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Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased. The initial changes were associated with the formation and subsequent dispersal of platelet clumps. The sequence of events resembled the reported...
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ژورنال
عنوان ژورنال: Rational Pharmacotherapy in Cardiology
سال: 2012
ISSN: 2225-3653,1819-6446
DOI: 10.20996/1819-6446-2012-8-2-168-172